Redox extracellular vesicles induce neurotoxic cytokine production from innate immune cells

BCG modulates neonatal innate immune cytokine production.

Infection causes 0.6 million of the total 2.9 million neonatal deaths every year and devastates the lives of millions more who initially survive; it mercilessly seeks out those weakened by premature delivery and/or low birth weight (LBW), an unfortunate combination too frequently encountered all over the world but particularly so in low-income countries [1]. Reduction of neonatal mortality over...

Dissecting innate immune signaling in viral evasion of cytokine production.

In response to a viral infection, the host innate immune response is activated to up-regulate gene expression and production of antiviral cytokines. Conversely, viruses have evolved intricate strategies to evade and exploit host immune signaling for survival and propagation. Viral immune evasion, entailing host defense and viral evasion, provides one of the most fascinating and dynamic interfac...

Production in Innate Immune Cells TLR-Mediated Inflammatory Cytokine The Role of JAK-3 in Regulating

TIM-3 regulates innate immune cells to induce fetomaternal tolerance.

TIM-3 is constitutively expressed on subsets of macrophages and dendritic cells. Its expression on other cells of the innate immune system and its role in fetomaternal tolerance has not yet been explored. In this study, we investigate the role of TIM-3-expressing innate immune cells in the regulation of tolerance at the fetomaternal interface (FMI) using an allogeneic mouse model of pregnancy. ...

Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

CD4 CD25 regulatory T (T R ) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved. Here, we have used Helicobacter hepaticus infection of T cell–reconstituted recombination-activating gene (RAG) / mice as a model to study the ability of CD4 CD25 T R cells to inhibit bacterially triggered...